Dr. Bradley Receives R01 Grant from NIH
Todd Bradley, PhD, Center for Pediatric Genome Medicine, was recently awarded a five-year, $2.9 million R01 grant from the National Institutes of Health – National Institute of Allergy and Infectious Diseases. Dr. Bradley’s “Natural killer cell regulation of the germinal center HIV neutralizing antibody response” study will determine key molecular pathways that are critical for natural killer (NK) cell immunoregulation of the HIV antibody response and evaluate the effects of modulating these responses in a preclinical HIV vaccine trial in nonhuman primates.
“Developing a safe and effective HIV vaccine is a top global health priority and a key component of a protective vaccine is eliciting antibodies that can neutralize the broad diversity of HIV viral strains,” Dr. Bradley said. “The results of our study will help identify novel NK cell-targeting strategies that can be applied during HIV-1 vaccination to improve immune responses.”
Children’s Mercy Kansas City is an independent, non-profit, 390-bed pediatric health system, providing over half a million patient encounters each year for children from across the country. Children’s Mercy is ranked by U.S. News & World Report in all ten specialties. We have received Magnet® recognition five times for excellence in nursing services. In affiliation with the University of Missouri-Kansas City, our faculty of nearly 800 pediatric specialists and researchers is actively involved in clinical care, pediatric research and educating the next generation of pediatricians and pediatric subspecialists. The Children’s Mercy Research Institute (CMRI) integrates research and clinical care with nationally recognized expertise in genomic medicine, precision therapeutics, population health, health care innovation and emerging infections. In 2021 the CMRI moved into a nine-story, 375,000-square-foot space emphasizing a translational approach to research in which clinicians and researchers work together to accelerate the pace of discovery that enhances care.