Kansas City,
24
August
2020
|
20:29 PM
Europe/Amsterdam

Dr. Feldman Receives Frontiers Grant to Develop Computational Framework to Improve Subject Matching in Retrospective Study Designs

Keith Feldman, PhD, Doctoral Research Faculty, was recently awarded a one-year, $23,597 Frontiers BERD Trailblazer Award from the University of Kansas Medical Center Research Institute.

The project, titled “Design of a computational framework to improve the quality of subject matching in case-control study designs,” seeks to utilize state-of-the-art data representations to identify optimal control subject(s) for a given case through a broader set of clinical and temporal criteria.

“Although randomized control trials represent the gold standard in evaluating clinical hypotheses, lengthy recruitment timelines and challenges in generalizability have prompted researchers to adopt alternative, large-scale observational study designs,” Dr. Feldman noted.

“Matched case-control (MCC) studies have become particularly common, pairing subjects who exhibit an outcome of interest (cases) with similar individuals who do not (controls). This pairing offers an effective means to study associations between exposures and outcomes, particularly for rare diseases or conditions with long latency periods. Unfortunately, current matching strategies are highly manual and focus on simplistic measures of demographics or disease state. These methods are also subject to significant bias and may overlook confounding factors or temporal relationships within subject histories.”

The study team, which includes Vince Staggs, PhD, is currently working to develop an automated framework to select matched controls in a faster and more balanced manner. Their approach focuses on utilizing the entirety of a subject’s medical history to better capture similarity in previous exposures.

Summary

Keith Feldman, PhD, Doctoral Research Faculty, was recently awarded a one-year, $23,597 Frontiers BERD Trailblazer Award from the University of Kansas Medical Center Research Institute.

About Us

Children’s Mercy Kansas City is an independent, non-profit, 386-bed pediatric health system, providing over half a million patient encounters each year for children from across the country. Children’s Mercy is ranked by U.S. News & World Report in nine specialties. We have received Magnet® recognition five times for excellence in nursing services. In affiliation with the University of Missouri-Kansas City, our faculty of more than 800 pediatric specialists and researchers is actively involved in clinical care, pediatric research and educating the next generation of pediatricians and pediatric subspecialists. The Children’s Mercy Research Institute (CMRI) integrates research and clinical care with nationally recognized expertise in genomic medicine, precision therapeutics, population health and health care innovation. In 2021 the CMRI moved into a nine-story, 375,000-square-foot space emphasizing a translational approach to research in which clinicians and researchers work together to accelerate the pace of discovery that enhances care.