Kansas City,
24
August
2020
|
20:29 PM
Europe/Amsterdam

Dr. Feldman Receives Frontiers Grant to Develop Computational Framework to Improve Subject Matching in Retrospective Study Designs

Keith Feldman, PhD, Doctoral Research Faculty, was recently awarded a one-year, $23,597 Frontiers BERD Trailblazer Award from the University of Kansas Medical Center Research Institute.

The project, titled “Design of a computational framework to improve the quality of subject matching in case-control study designs,” seeks to utilize state-of-the-art data representations to identify optimal control subject(s) for a given case through a broader set of clinical and temporal criteria.

“Although randomized control trials represent the gold standard in evaluating clinical hypotheses, lengthy recruitment timelines and challenges in generalizability have prompted researchers to adopt alternative, large-scale observational study designs,” Dr. Feldman noted.

“Matched case-control (MCC) studies have become particularly common, pairing subjects who exhibit an outcome of interest (cases) with similar individuals who do not (controls). This pairing offers an effective means to study associations between exposures and outcomes, particularly for rare diseases or conditions with long latency periods. Unfortunately, current matching strategies are highly manual and focus on simplistic measures of demographics or disease state. These methods are also subject to significant bias and may overlook confounding factors or temporal relationships within subject histories.”

The study team, which includes Vince Staggs, PhD, is currently working to develop an automated framework to select matched controls in a faster and more balanced manner. Their approach focuses on utilizing the entirety of a subject’s medical history to better capture similarity in previous exposures.

Summary

Keith Feldman, PhD, Doctoral Research Faculty, was recently awarded a one-year, $23,597 Frontiers BERD Trailblazer Award from the University of Kansas Medical Center Research Institute.

About Us

Children’s Mercy Kansas City is ranked as one of “America's Best Children's Hospitals” in all 10 specialties rated by U.S. News & World Report and has received MagnetTM recognition for excellence in nursing services four consecutive times. With 366 licensed beds and a medical staff of more than 750 pediatric subspecialists, we care for children from all 50 states and from around the world. In addition, our leadership in pediatric genomic medicine and individualized pediatric therapeutics is driving research and innovation in neonatology, nephrology, endocrinology, gastroenterology, neurology, heart, cancer and other subspecialties to transform outcomes for children. Children’s Mercy also is nationally recognized for innovation in psychosocial care and creating a family-centered environment focused on the unique needs of hospitalized children and their families. Our love for children powers everything we do, inspiring our research, innovations and our everyday care. Because love has no limits. And with it, neither do we.