Dr. Shakhnovich Receives $50,000 Award for Obesity Research
Valentina Shakhnovich, MD, Clinical Pharmacology & Gastroenterology, received a one-year, $50,000 Pilot Award from Frontiers: University of Kansas Clinical and Translational Science Institute.
Dr. Shakhnovich’s study, “Effect of Liver Adiposity on Hepatic Drug Metabolism in Children,” aims to help bridge the gap in knowledge to guide appropriate drug dose selection for pediatric patients with obesity, many of whom have increased fat in the liver. By investigating the consequences of obesity on drug metabolism in the liver, Dr. Shakhnovich and her NIH-funded team are generating novel in-vivo data for hepatic drug-metabolizing pathways (CYPs) most relevant to human health. This study will measure the effect of liver fat on CYP3A4 activity in children undergoing weight reduction. It will also identify plasma biomarkers of clinically significant changes in hepatic fat using an untargeted metabolomics approach.
“The long-term mission of my research program is to develop physiologically-informed drug dose selection tools for patients with obesity and help clinicians choose the right dose of medications for this understudied patient population,” Dr. Shakhnovich wrote.
Earlier this year Dr. Shakhnovich received a K23 award from the National Institutes of Health. Together, these two awards will move forward the field of precision therapeutics for children with obesity.
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