McLaughlin Selected as Neurorehabilitation and Restorative Training Network K12 Scholar on Grant from NIH/NICHD
Study title: Precision medicine in pediatric patients with Cerebral Palsy
Matthew J. McLaughlin, MD, Pediatric Physical Medicine/Rehabilitation, has been selected as a Neurorehabilitation and Restorative Training Network (NRNTN) K12 Scholar on a two-year, $250,000 grant from the National Center for Medical Rehabilitation Research (NIH/NICHD).
Dr. McLaughlin and his study team will be working to improve the understanding of baclofen metabolism, distribution and response in pediatric patients with Cerebral Palsy as a part of the GOLDILOKs framework developed by Clinical Pharmacology. Baclofen is the most commonly prescribed oral medication for spasticity, but little is known about its efficacy or distribution into the central nervous system.
This study, called “Precision medicine in pediatric patients with Cerebral Palsy,” looks at plasma to CSF levels to determine how much baclofen crosses the blood-brain barrier and also correlates plasma concentrations to how much clinical response is seen.
“My long-term goal is to establish an independent precision medicine-based research program that improves functional outcomes in neurorehabilitation patients by investigating inter-individual differences in dose-exposure-response relationships,” said Dr. McLaughlin. “This is the first study to utilize the innovative approach of linking precision medicine to corresponding functional outcomes in neurorehabilitation patients. These aims, conducted in independent cohorts of children, construct a model that allows improved dosing recommendations for pediatric patients with functional impairments, ultimately improving the way in which providers prescribe therapeutic interventions for patients requiring neurorehabilitation.”
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